A New Theory Of MHC Evolution: Beyond Selection On The Immune Genes

I propose a new theory that can explain the evolution and population genetics of vertebrate immune genes, the Major Histocompatibility Complex (MHC).


The theory is called Associative Balancing Complex evolution (ABC evolution), and it can explain the origin of the large number of genetic disorders associated with the MHC genes in humans, as well as several other remarkable features of these genes.


ABC evolution is inspired by theoretical studies of self-incompatibility loci (S-loci) of plants, and it incorporates the effects of evolutionary forces (mutation, selection, genetic drift and recombination) that act on the genes linked to the MHC.


Proceedings of the Royal Society B: Biological Sciences


Proceedings B is the Royal Society's flagship biological research journal, dedicated to the rapid publication and broad dissemination of high-quality research papers, reviews and comment and reply papers. The scope of journal is diverse and is especially strong in organismal biology.


Proceedings of the Royal Society B: Biological Sciences

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